In ancient times, Masserano was the capital of the ancient principality which extended to the borders of Valsesia. Become the Principality in 1598, with Francesco Filiberto first Prince of Masserano, until 1741, the rich heritage left by the princes of the village are now kept in the Polo Muserano Masseranese, which includes: the Royal Palace of the Ferrero-Fieschi Princes, the Collegiate Church, the Church of San Teonesto and the Church of Santo Spirito.
