Its foundation dates back to the period between the X and XI century, which was followed by an enlargement in 1546; further work at the end of the XVII century gave the current form. Has a renaissance style facade, while its interior is typically baroque and rich in works of art. In the apse you can admire the Annunciation, a fresco attributed to Masolino da Panicale. The altar preserves a wooden crucifix of the sixteenth century with the swing arms, used in ancient times to the processions of the Holy Week. At the top there are six medallions to fresco of the Seventeenth century depicting a cycle of the Stories of the Virgin Mary.
In the third altar on the left is the blade of the Nativity, the adoration of the shepherds (1519) of Giovan Battista Caporali, pupil of Perugino. There are also other tele: The Last Supper, datable around the end of the XVIII century, by an unknown author; the Crucifixion of Saint Ignatius of Loyola, St Philip the Apostle, Saint Francis Xavier and Saint Jerome, attributed to Bartolomeo Barbiani (1640 approximately); the San Pellegrino di Tommaso Conca. Also significant component Morettini, dating back to 1835. Since 2001 component Morettini is celebrated every year in summer on the occasion of the Organ Festival Morettini.